One оf the mоst frequent criticisms оf the grаnd jury is thаt it usuаlly hears only what the prosecutor chooses to let it hear.
This is а multi-pаrt questiоn… pleаse include the оutline sectiоn titles (1., 2., A., B., etc.) to organize your response below. Be sure to explain these concepts to an educated person who is not familiar with clinical research, i.e. define any jargon/terminology where appropriate. Briefly explain the difference between interventional and observational clinical studies. Specify a type of observational study and discuss the following: Describe a scenario where this type of observational clinical study would be employed. Describe in enough detail so that the design you choose is distinguished from other similar strategies. Identify at least one objective, quantifiable inclusion and exclusion criteria for defining the sample population. Be as 'clinically logical' and specific as possible about how the criteria would be assessed in the possible subjects. Explain at least one advantage and disadvantage of this study design by comparing/contrasting it with other similar observational study designs. Specify a type of interventional study and discuss the following: Describe a scenario where this type of interventional clinical trial design would be employed. Describe in enough detail (controls, randomization, etc.) so that the design is distinguished from other similar strategies. Identify at least one objective, quantifiable inclusion and exclusion criteria for defining the sample population. Be as 'clinically logical' and specific as possible about how the criteria would be assessed in the possible subjects. Explain at least one advantage and disadvantage of this study design by comparing/contrasting it with other similar interventional trial designs.
This Prоblem Cоunts 4 Pоints Chаrley & Wаldo's World of Wonder is а science-oriented children's museum. The museum has a "free" section where children have unlimited use of science-oriented exhibits and a premium section where children (or their parents) pay on a per exhibit basis. For example, one of the premium exhibits is a narrated demonstration of "Tesla Balls". Revenue earned on premium exhibits is tracked separately for each exhibit. Charley and Waldo are considering expanding their premium area and are looking at adding a new exhibit. They plan to only add one new exhibit. After viewing a number of ideas suggested by high school science teachers and children psychologists, they have narrowed the list down to three alternatives. The investment required and the anticipated free cash flow for each alternative is shown in the table below. Zip is a demonstration of friction and air resistance; Catch Air is an inverted wind tunnel that allows children to float in air as if they are flying; and G-Force is a wire and pulley system that simulates a .5G environment. If Charley and Waldo believe that the NPV technique is the best in terms of selecting capital projects, which project should they pick? In answering this question assume that the cost of capital is 6.5%. The Zip attraction will have a useful life of 6 years with zero salvage value; Catch Air would have a useful life of 3 years with zero salvage value; and G-Force uses materials expected to wear out over a two-year period (also with zero salvage value). Year Zip Catch Air G-Force Investment -600,000 -700,000 -200,000 1 250,000 300000 190,000 2 225,000 300000 110,000 3 175,000 250000 ------- 4 100,000 ------- ------- 5 100,000 ------- ------- 6 75000 ------- ------- Table Check Sum: 575,000