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Adоlescents with аutism spectrum disоrder will hаve vаrying degrees оf impairment in their social and behavioral function, so treatment must be individualized based on the patient's age and their needs. Family education, behavioral and educational interventions, and counseling have a significant place in this treatment plan. Pharmacotherapy may be considered, but should be used as adjunctive therapy. Children and adolescents with AS are treated via pharmacotherapy mainly to assist in control of their psychiatric symptoms; these patients are much more sensitive to medication effects. It is suggested to initially start the patient on a selective serotonin reuptake inhibitor (SSRI) (e.g., sertraline or fluoxetine) or SNRI for anxiety symptoms. Aripiprazole is FDA approved and has been found to ease symptoms of irritability, aggression, temper tantrums, rapidly changing moods, and even self-injuring behavior in both children and adolescents with ASD. When beginning any pharmacotherapy for such patients, having a "start low and go slow" regimen is strongly recommended, with consistent follow-up visits for evaluation of alleviation of the symptoms.