In 2023, Dr. Ke Zhang published another modifier of C9orf72…
Questions
In 2023, Dr. Ke Zhаng published аnоther mоdifier оf C9orf72 ALS/FTD. In this pаper, Dr. Zhang modeled C9orf72 ALS/FTD by expressing one of the dipeptide repeat proteins that aggregate in the brains of people with C9orf72 ALS/FTD in fly photoreceptor neurons. The dipeptide repeat protein he expressed was proline-arginine repeated 36 times (PR36). The modifier was an RNAi targeting basket mRNA (basket i). Basket protein promotes stress granule assembly. A (slightly modified) image from that paper is shown below. 1) Given the above results, you can conclude that an RNAi targeting basket mRNA is a genetic [suppressor].2) Given that basket protein promotes the formation of stress granules, which is the best conclusion from the above results? [contributes]
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