Your next patient is a 62 year old ex-smoker who has been re…

Your next patient is a 62 year old ex-smoker who has been referred to you for symptomatic squamous cell lung cancer. He has lost some weight, has some bony pain from his metastatic disease, and coughs frequently, but without hemoptysis. He also has dyspnea on exertion from his modest pleural effusion, though that is better after the pulmonologist performed a therapeutic and diagnostic thoracentesis. In addition to cytologic stains for diagnosis, the pathologist tells you that 85% of his cells express PD-L1. The patient doesn’t want chemotherapy, but he might consider it if he has to. What might be a good option for him?

A cancer researcher has isolated a new gene that may be invo…

A cancer researcher has isolated a new gene that may be involved in the growth and differentiation of muscle cells. Moreover, the researcher has demonstrated mutations of this gene in the tumor cells from childhood rhabdomyosarcomas. Subsequent experimental studies were performed. Which of the following constitutes the best evidence that the newly isolated gene functions as a tumor suppressor gene?