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Unproductive rearrangement of the BCR genes on both chromosomes leads to:

MHC restriction:

MHC restriction:

How many hypervariable regions (HV’s) does the (a) alpha chain of a T-cell receptor have?

What is present during the first checkpoint in B-cell maturation?

RAG-1 and RAG-2 enzymes are expressed in almost all nucleated cells to rearrange the TCR and BCR variable region genes.

How many hypervariable regions (HV’s) does the (a) alpha chain of a T-cell receptor have?

Which of the following is true about the pre-B-cell?

Which cell types can become a plasma cell?

Successful rearrangement of ______ leads to the deletion and inactivation of the ______ due to its location.