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In the paper by Papasergi-Scott et. al. the authors examine how phosphorylation affects Ric-8A function. Describe the experimental setup and the main conclusion gleaned from the following figure?  

The following True/False question pertains to the journal article discussed in class, IkB: A Specific Inhibitor of NF-kB Transcription Factor IkB was shown to be a specific inhibitor of NF-kB in EMSAs, but not other transcription factors, such as OCTA, AP-1, etc. 

What enzymes turn off signaling from RTK’s by removing the phosphate modifications on target proteins?

Is the p65/p50 heterodimer primarily a repressor or activator of transcription?

The following figure plots ERK and adenylyl cyclase activity in response to various b2-AR ligands.  Given the data in the figure, determine whether Radicolol (Rad) is biased or unbiased.  

What proteins contain a Rel Homology Domain (RHD) and what are the functional roles of the subdomains RHR-N and RHR-C?

The following figure plots ERK and adenylyl cyclase activity in response to various b2-AR ligands.  Given the data in the figure, determine whether Propanolol (Prop) is biased or unbiased.  

Single nucleotide polymorphisms (SNPs) have been discovered that can affect GPCR function.

What enzyme is essential for Wnt production?

The following True/False question pertains to the journal article discussed in class, IkB: A Specific Inhibitor of NF-kB Transcription Factor Enucleated cells were used to demonstrate that the NF-kB/IkB complex was cytoplasmic.