You are examining a term female neonate who was born after a…

You are examining a term female neonate who was born after an uneventful pregnancy to a 31 year old, gravida 2 para 1 mother by normal spontaneous vaginal delivery. On examination, the infant weighs 2.56kg and has mild diffuse hypotonia. He also has slightly short fingers and toes, simian creases, flat facial profile, upslanting palpebral fissures, and small ears. Of the following, the most likely diagnosis is:

A couple comes to you with questions following the diagnosis…

A couple comes to you with questions following the diagnosis of Trisomy 21 in their now 18 week fetus. They ask what medical problems may be anticipated for a child who has Down syndrome. Of the following, the medical problem that is encountered most frequently in infants who have Trisomy 21 is