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Which of the following medications contribute to electrolyte anomalies in TLS patients?

TG is a 59-year-old male who has recently been diagnosed with mantle cell lymphoma. He is receiving the NORDIC regimen (alternating regimens with regimen 1: rituximab, cyclophosphamide, vincristine, doxorubicin, prednisone and regimen 2: rituximab and high-dose cytarabine). He comes into the oncology clinic and you notice he has an unbalanced gait, nystagmus, and a prolonged separation of syllables. You think he might be having cerebellar neurotoxicity due to his chemotherapy. Which medication in his regimen is most likely contributing to his symptoms?  

Dr. Myran – Rheumatology

(Oung Depression/Anxiety/Sleep Disorders) WZ is a 32 yoF with a history of major depressive disorder. She presents to clinic today after starting fluoxetine 20mg daily 5 weeks ago. She is in otherwise good health. When questioned, AR states her medication “is just not working at all” and endorses feelings of hopelessness about life and having difficulty concentrating at work. She states that she has also been feeling pressure lately as her family continues to ask her if she plans on having children soon. She and her husband are currently trying to conceive. You ask her to fill out a PHQ-9, which reveals a score of 15. Assuming she has not tried any other medications, which of the following is the best treatment option for this patient?

AQ is a 52-year-old woman who presents to clinic for follow-up with her PCP to discuss worsening hot flushes.  She explains that she has to get up in the night and change the bedding, is unable to work a full day at her job at least once per week.  In addition, she feels “moody and down in the dumps” most days of the week, for a couple of months now.  Her health history includes hypertension, hyperlipidemia, Crohn’s disease, recurrent DVT and PE, and she did have a hysterectomy after her last daughter was born 21 years ago, due to complications.  She reports that she is at a “point of desperation to feel like myself again”.  The physician appreciates and accepts your recommendation for the treatment of AQ’s vasomotor symptoms.  Now that she has had time to review the patient’s recent bone density scan, she would like you to make a recommendation for an oral bisphosphonate to treat the patient’s newly diagnosed osteoporosis.  Which of the following is a true statement?

Which medication carries a recommendation for use in preventing TLS of high-risk?

(Vandiver Seizure) Clinically significant drug-drug interactions are MOST likely with which of the following antiepileptics?

(Mann ICU-2) According to the 2018 PADIS Guidelines, which of the following choices best represents a preferred approach to sedation in a critically ill patient?

Which of the following is the most important determinant for discontinuing antibiotic therapy? 

JG is a 49-year-old female referred to your pharmacotherapy clinic for a consult related to symptoms of vaginal dryness, severe hot flashes, and night sweats.  JG reports her current symptoms have been a problem for 6-8 months and her primary care provider has prescribed topical estrogen without benefit.  Additionally, she has tried evening primrose and black cohosh and those have not worked.  Her most recent vaginal exam was normal, she has an intact uterus, and she has no history of thromboembolism. Her current medical problems include dry eyes, migraine without aura, and hypertension. Her current medications are hydrochlorothiazide 25mg daily, topiramate 100mg twice daily, sumatriptan 100mg at onset of migraine, may repeat one time in 24-hour period, and ibuprofen 400mg two or three times daily as needed.  All medications are prescribed by referring physician.  What product would you recommend as the best treatment for JG?