Author: Anonymous

RAG-1 and RAG-2 enzymes are expressed in almost all nucleated cells to rearrange the TCR and BCR variable region genes.

How many hypervariable regions (HV’s) does the (a) alpha chain of a T-cell receptor have?

Which of the following is true about the pre-B-cell?

Which cell types can become a plasma cell?

Successful rearrangement of ______ leads to the deletion and inactivation of the ______ due to its location.

In which of the following stages are the Ig genes for the light chain still in their germline configuration?

Successful rearrangement of ______ leads to the deletion and inactivation of the ______ due to its location.

You would expect to see Igα and Igβ genes turned on (expressed) during the large pre-B cell stage.

Which gene segment is located within the α-chain locus and is consequently deleted and inactivated once the α gene rearranges it’s gene segments?

Imagine you’re a doctor and you discover your infant, recently born patient has thrush. You order genetic sequencing and find that the RAG-1 gene doesn’t produce a functional enzyme.  From what you have learned in this class and with this information at hand, you can conclude that: