Author: Anonymous

What proteins contain a Rel Homology Domain (RHD) and what are the functional roles of the subdomains RHR-N and RHR-C?

Single nucleotide polymorphisms (SNPs) have been discovered that can affect GPCR function.

The following figure plots ERK and adenylyl cyclase activity in response to various b2-AR ligands.  Given the data in the figure, determine whether Propanolol (Prop) is biased or unbiased.  

What enzyme is essential for Wnt production?

Name two domains which commonly bind to tyrosine phosphorylated RTK’s?

In the paper by Mueller and colleagues entitled “The receptors and coding logic for bitter taste”, the authors use multiple approaches to alter mice such that they can make mice “taste” molecules (such as Phenyl-b-D-glucopyanoside) to which wildtype mice are normally insensitive. Describe the experimental approach that the authors took in this manuscript to demonstrate that they can generate mice able to respond favorably (as if it was a sweet substance) or negatively (as if it was a bitter substance) to the Phenyl-b-D-glucopyanoside. 

The following True/False question pertains to the journal article discussed in class, IkB: A Specific Inhibitor of NF-kB Transcription Factor Enucleated cells were used to demonstrate that the NF-kB/IkB complex was cytoplasmic.

GPCRs function as exchange kinases to phosphorylate GDP thus providing G-proteins access to GTP.

For the EGF receptors an allosteric mechanism is used to activate the kinase domains

GPCRs can play important roles in the immune system function by directing neutrophil, macrophage, and lymphocyte migration and/or cellular activation during an immune response