A 24-yeаr-оld femаle presents tо the Internаl Medicine оffice with a seven-day history of abdominal pain, and now bloody diarrhea. Review of systems is notable for a 12-pound unintentional weight loss and intermittent loose stools. She has a family history significant for a father with CAD and a mother with primary sclerosing cholangitis. Upon further workup, she is found to have continuous colonic mucosal inflammation on colonoscopy and crypt abscesses noted on biopsy. Serum perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) is positive. This patient's disease is likely to also include which of the following features?